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Spilanthol, whose term in the official IUPAC nomenclature is: (2E,6Z,8E)-N-(2-Methylpropyl)deca-2,6,8-trienamide, is a fatty acid amide, with the molecular formula: C14H23NO .
Spilanthol is a substance isolated from Acmella oleracea, a plant native to South America and tropical Africa, widespread in Australia, India, Malaysia and Sri Lanka.
It is believed that this amide is responsible for the local anesthetic properties of the plant.
Spilanthol contributes to permeate human skin and the lining of the cheeks in the mouth, i.e. the mucosa, resulting in local and systemic drug concentrations.
In the skin and pancreas, spilanthol has also been shown to exert anti-inflammatory effects.
The mechanism involves inhibition of nitric oxide production due to reduced expression of the enzyme inducible nitric oxide synthase (iNOS) in macrophages. Transcription factor array experiments revealed that spilanthol inhibits the activation of several transcription factors (NFκB, ATF4, FOXO1, IRF1, ETS1 and AP-1) which may explain the effect of spilanthol on gene expression.
Due to its properties, spilanthol helps to relax the skin and eliminate wrinkles with a natural lifting effect, very similar to the effect of botulinum toxin but in this case completely natural.
The effectiveness of spilanthol extract on the skin in the cosmetic field has been demonstrated in the last 10 years by various scientific studies.
Spilanthol slows down the formation of wrinkles as it relaxes the muscles of the face and therefore performs an effective action against the signs of aging. It is also a fast and progressive muscle relaxant substance that acts on the muscles found under the skin, reducing the muscle contractions that are at the origin of expression wrinkles on the skin of the face.

Spilanthol has been widely used in traditional medicine for several centuries in South America and in traditional Chinese medicine to treat even very different ailments. The main traditional use of spilanthol is as an analgesic, in fact it effectively manages to decrease toothache, rheumatism pains and headaches.
In general, the properties of spilanthol are:
– Antiseptics;
– Antibacterial;
– Antifungal.
Spilanthol stimulates the immune system and is therefore excellent for use in the presence of colds and fever.
It is also used in the presence of candidiasis and herpes as an antifungal and used in various digestive system disorders such as stomach pain and diarrhea.
Thanks to its antibacterial properties it is also used in case of cuts, blisters, wounds and pimples on the skin of the body.

Warning: The information provided is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.

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