Amaroswerin
Amaroswerin
Amaroswerin, whose term in the official IUPAC nomenclature is: [(2S,3R,4S,5S,6R)-2-[[(3S,4R,4aR)-4-ethenyl-4a-hydroxy-8-oxo- 3,4,5,6-Tetrahydropyran[3,4 -c]pyran-3-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxane-3-yl]2,4-dihydroxy-6- (3-hydroxyphenyl)benzoate, is a secoiridoid glucoside with the brute or molecular formula: C29H30O14.
Amaroswerin is a molecule of natural origin produced by the biochemistry of some plants, such as: Swertia japonica, Gentianella nitida, Swertia mussati, Gentiana lutea and others where its presence has been ascertained up to now.
Amaroswerin has demonstrated some anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory activities.
Among other functions, amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells.
In this regard, some of the activities recognized in Gentiana lutea are attributable to this molecule, together with other active ingredients contained in the plant such as, in addition to amaroswerin: amarogentin, gentiopicroside, gentiopicroside, amaropanin, gentiobiose and swertiamarin, in addition to the alkaloids: gentianin and gentialutin and to the bitter trisaccharide gentianose and others.
In this sense, Gentian is useful for the digestive function, for the liver function and favors the elimination of intestinal gas.
These properties are attributable to the action of the bitter substances contained in the drug, in particular to the action of the iridoid glycosides amarogentin and amaroswerin. These substances stimulate the taste receptors, which in turn stimulate the production of saliva and gastric juices by reflex. All this translates into an increase in appetite and an improvement in digestive function.
In this regard, the bitterness index of the main active ingredients is reported:
– Amarogentin: 58,000,000;
– Amaroswerin: 58,000,000;
– Bitterpanin: 20,000,000;
– Gentiopicroside: 12,000,000.
Gentian also has choleretic properties: it stimulates the emptying of the gallbladder, a useful function for maintaining good liver and digestive activity.
Warning: The information provided is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.