Cyclosporine

Cyclosporine

Cyclosporine is a natural peptide with the brute or molecular formula: C62H111N11O12.
Cyclosporine is a naturally occurring substance extracted from the fungi Trichoderma polysporum and Cyclindrocarpon lucidum.
The properties of this substance are very useful as they are immunosuppressive; for over thirty years it has been adopted as a treatment for organ transplant rejection reactions and in numerous immune-mediated diseases.
Cyclosporine acts mainly on T lymphocytes, inhibiting their proliferation by inhibiting the production of pro-inflammatory molecules such as interleukin 2.
This substance, together with Tacrolimus (FK506), is one of the main therapeutic agents used to block allogeneic transplant rejection.
Furthermore, from the first observations, which occurred almost by chance, numerous clinical studies over the years have confirmed its beneficial effects and today the efficacy of cyclosporine in the treatment of psoriasis is now widely consolidated. However, the potential appearance of side effects such as hypertension, renal dysfunction and the onset of malignancies associated more frequently in the long term and with high doses of anti-transplant rejection therapies, still makes some doctors reluctant to administer cyclosporine in cases of moderate psoriasis. serious.

Warning: The information provided is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.