Silibinin

Silibinin

Silybinin, or silybin, whose brute or molecular formula is: C25H22O10, is a compound of the flavonolignan family.
Silybinin is the main active constituent of silymarin, a standardized extract obtained from the milk thistle achenes (Silybum marianum (L.) Gaertn., 1791) which contain a mixture of flavonolignans including silybinin, isosilibinin, silychristin and silydianine.
In turn, silybinin is a mixture of two diastereoisomers, silybinin A and silybinin B which are almost equimolar in ratio.
Silybinin is used in the treatment of toxic liver diseases (e.g. intravenously in case of poisoning with Amanita phalloides); it is also used as an adjuvant therapy in chronic liver diseases and liver cirrhosis.
In addition, Silibinin can play an interesting role in the fight against Piorrea (periodontal disease, periodontitis or periodontal disease).

This active ingredient is a phytoestrogen, antioxidant, regulator of the entero-hepatic cycle; it is a powerful cholagogue and detoxifier of the liver and deactivates Beta-glucuronidase.
The link between the oral bacterial plaque and the intestinal bacterial flora is given by the Beta-glycuronidase produced in the liver which is responsible for eliminating: estradiol, cortisol, cholesterol and carcinogens.
In intestinal dysbiosis and intestinal inflammation, which are connected to each other, there is an increase in Beta-glucuronidase, as well as an increase in the reabsorption of the aforementioned estrogens with hyperestrogenism, responsible for hormonal periodontitis, which generate a Th2 type organic reactivity.
It is a picture of Chronic Stress that leads from Hyperglycaemia to Diabetes, that is, to hormone-sensitive periodontitis, aggravated by intestinal malabsorption.

Warning: The information shown is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.