Protoveratrine
Protoveratrine
Protoveratrine is a substance of natural origin whose term in the official IUPAC nomenclature is: [(1S,2S,6S,9S,10S,11R,12R,13S,14S,15S,16S,17R,18R,19S,22S,23S ,25R)-16,17-diacetyloxy-10,12,14,23-tetrahydroxy-6,10,19-trimethyl-13-[(2R)-2-methylbutanoyl]oxy-24-oxa-4-azahheptacyclo[12.12 .0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] (2S)-2-hydroxy-2-methylbutanoate.
Protoveratrine has a molecular formula: C41H63NO14 and is a substance found in some plants of the Veratrum genus, such as Veratrum album and Veratrum viride.
These plants are also known as hellebore and grow in various parts of the world, including Europe, Asia and North America.
Protoveratrine is a highly toxic substance that can have serious effects on the human body if ingested or absorbed.
Each of the two alkaloids isolated from Veratrum Album have hypotensive properties. Named protoveratrine A and B, they are often combined for their therapeutic effect. Protoveratrine B is less potent than protoveratrine A.
Hellebore plants have historically been used in some folk medical traditions, but due to their toxicity, their use is extremely dangerous and generally not recommended. Protoveratrine acts as a powerful vasoconstrictor, meaning it can narrow blood vessels, leading to increased blood pressure. This can be extremely dangerous and can cause a number of adverse symptoms, including nausea, vomiting, sweating, and in severe cases, seizures and heart problems.
Protoveratrine and hellebore plants are not generally used in modern medicine due to their toxicity. However, some substances derived from hellebore plants, such as jervina, have been studied for their possible pharmaceutical applications in the medical field, but remain the subject of research and experimentation.
It is important to note that the use of hellebore plants and their toxic substances is dangerous and should not be attempted without appropriate medical supervision.
Warning: The information provided is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.