Nardosinone, whose term in the official IUPAC nomenclature is: (3aR, 9R, 9aR, 9bS) -1,1,9,9a-Tetramethyl-1,3a, 4,7,8,9,9a, 9b-octahydro- 5H-naphtho [2,1-c] [1,2] dioxole-5-one, is a sesquiterpene with a brute or molecular formula: C15H22O3.
Nardosinone is a naturally occurring substance and has been isolated from Nardo root (Nardostachys jatamansi (D.Don) DC.).
Nardo is an important Chinese herbal medicine; it is a nerve growth factor enhancer and has a wide range of pharmacological effects, including sedatives, adaptogens, antidepressants, antileukemics, antitumor and anticancer effects.
In in vitro studies, nardosinone demonstrated a concentration enhancement dependent on the neurite growth induced by bucladesin and staurosporine.
Similarly, nardosinone has been shown to enhance NGF-mediated neurite growth and synaptogenesis from PC12D cells.
Furthermore, nardosinone demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.
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