Bergenin, of which the term Cuscutin is synonymous, is a glycoside of trihydroxybenzoic acid, and in particular the C-glycoside of 4-O-methyl gallic acid.
Bergenin, whose brute chemical formula is: C14H16O9, in the IUPAC nomenclature takes the name of: (2R, 3S, 4S, 4aR, 10bS) -3,4,8,10-tetrahydroxy-2- (hydroxymethyl) -9- methoxy-3, 4,4a, 10b-tetrahydro-2H-pyran [3,2- c] isochromen-6-one.
Bergenin has a derivative, O-demethylated, called norbergenine. These are chemical compounds used as drugs in Ayurveda medicine, commonly known as Paashaanbhed.
Bergenin, or Cuscutin, has a notable immune-modulating effect and is naturally present in some plants.
Bergenin can be extracted and isolated from some pints of the genus Bergenia, such as Bergenia ciliata (Haw) Sternb. and Bergenia ligulata (Wall.) Engl., from the rhizomes of Bergenia stracheyi (Hook.f. & Thorns.) Engl ..
It is also found in the bark of the stem of Dryobalanops aromatica Gaertn.f., In Ardisia elliptica Thunb. and in Mallotus japonicus (L.f.) Müll.Arg ..
We find it, moreover, with the name of Cuscutin, which as mentioned is synonymous with bergenin, in Cuscuta europaea L.
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