Kaempferol

Kaempferol

Kaempferol, whose name in the official IUPAC nomenclature is: 3,4 ′, 5,7-tetrahydroxyflavone and whose brute or molecular formula is: C15H10O6 is a natural flavonol that occurs in the form of a yellow crystalline solid with a melting point of 276–278 ° C.
Kaempferol is slightly soluble in water and highly soluble in hot ethanol and ethers and acts as an antioxidant reducing oxidative stress.
It is found in many plants and foods obtained from these.
Among the plants we remember: Aloe vera, Coccinia grandis, Cuscuta chinensis, Euphorbia pekinensis, Glycine max, Hypericum perforatum, Pinus sylvestris, Moringa oleifera, Rosmarinus officinalis, Sambucus nigra, Toona sinensis, Ilex and others.
The common foods that contain kaempferol are: apples, grapes, tomatoes, green tea, potatoes, onions, broccoli, Brussels sprouts, pumpkins, cucumbers, lettuce, endive, green beans, peaches, blackberries, raspberries, and spinach.

Many studies suggest that the consumption of kaempferol may reduce the risk of various cancers and is currently considered a possible treatment for cancer.
Other studies have shown that kaempferol and some glycosides derived from kaempferol perform a wide range of pharmacological activities, including antioxidants, anti-inflammatories, antimicrobials, anticancer, cardioprotective, neuroprotective, antidiabetic, antiosteoporotic, estrogenic / antiestrogenic, anxiolytic and antiallergic.
Kaempferol is ingested as glycoside, absorbed in the small intestine, usually by passive diffusion due to kaempferol lipophilicity and metabolized in various areas of the body. In the small intestine, kaempferol is metabolised to glucuronides and sulfated by intestinal enzymes. It can also be metabolized by colon microflora which can hydrolyze glycosides in aglycones or form simple phenolic compounds. These compounds can be absorbed or excreted. Kaempferol is also extensively metabolized in the liver to form conjugated forms with glucurene and sulfur. These forms and the kaempferol itself can therefore be excreted in the urine. On average about 2.5% of the ingested kaempferol is excreted in the urine.

Warning: The information given is not medical advice and may not be accurate. The contents are for illustrative purposes only and do not replace medical advice.



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